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Application Note 110 – ViriChip™ platform for Ultraminiaturized Direct Sensing Virus Detection

In this application note, we demonstrate a novel label free method for direct virus sensing. The Nano eNabler™ system is used to create ultraminiaturized antibody arrays with spot sizes (10 to 15 µm) in discrete locations. These spots occupy 1/100th to 1/1000th the surface area of a conventional microarray (D=100 µm) spot [1]. The ultraminiaturized spatial scale made possible by the Nano eNabler™ system creates an opportunity for direct readout by surface profiling using the principles of atomic force microscopy (AFM) along with more conventional methods. Viruses remain bioactive and amenable to culture and PCR.

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