MIT Researchers Report Results of Use of BioForce Nanosciences’ Nano eNabler Molecular Printer

Nano eNabler Provides Ability to Construct Protein Microarrays Allowing Control of Cellular Alignment 

AMES, IA, October 28, 2008 — BioForce Nanosciences Holdings, Inc. (OTC BB: BFNH), a leader in systems integration at the micro and nano scales to create products for the life sciences, is pleased to announce that researchers at the Massachusetts Institute of Technology (“MIT”) have published their latest work with the Nano eNabler™ molecular printer in the nanotechnology journal Small.  The manuscript, titled “Cell-Compatible, Multi-Component Protein Arrays with Subcellular Feature Resolution” was released online on October 10, 2008, and is in the October print issue of the journal.

In their paper, Ying Mei, Ph.D. and Daniel Anderson, Ph.D., post-doctoral researchers in the laboratory of Professor Robert Langer, demonstrate the fabrication with the Nano eNabler of micro scale arrays containing large numbers of single-component and multiple-component protein spots of varying densities to study the adhesion and spreading of mouse muscle cells.  The researchers discovered that through use of the Nano eNabler they were able to create protein arrays which allowed them to align the mouse cells that had been deposited onto the arrays.  This ability to control the alignment of cells has utility in the growth of organized cellular structures, an important prelude to future work in the areas of stem cell differentiation and tissue engineering.

BioForce’s Product Manager, Michael Lynch, said, “We are proud to have our technology validated by such a high-profile lab.  This publication demonstrates the effectiveness of the Nano eNabler for constructing complex cellular microenvironments.  The market’s need for the Nano eNabler is demonstrated by the researchers’ comments in the paper about the Nano eNabler’s unique ability to effectively create arrays containing the desired one to ten microns feature sizes.  Without the Nano eNabler’s capabilities, this project, and the future work to be performed by MIT and other Nano eNabler users in areas such as stem cell differentiation and tissue engineering, would not be possible.”

On October 23, 2008, Dr. Ying Mei presented the findings published in their paper through a free BioForce-hosted online seminar.  The title of his webinar presentation was “Cell-Compatible, Multi-Component Protein Arrays with Subcellular Feature Resolution” and interested viewers may download a video of the webinar from the BioForce Resources Library.

For further information about this release please contact Greg Brown, Chief Financial Officer of BioForce at 515-233-8333 ext. 118, or Rich Kaiser, Investor Relations at 800-631-8127.


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