While the last SARS outbreak did cost the global economy $11 BN, a potential Avian Flu pandemia can cost $800 BN and millions of lives. The 4.5 million US cases of Hepatitis C costs the US healthcare $9 BN annually. There are 40 million worldwide cases of HIV and it continues to spread, partially due to lack of reliable detection.
BioForce Nanosciences developed a platform for fast, sensitive and non-destructive virus detection. The platform consists of a silicon chip functionalized with an ultramicro array of antibodies using the Nano eNablerTM, and a detection system based on Atomic Force Microscopy.
- Detects actual viruses, not their byproducts
- Minimizes false positives
- Incubation and detection take 30 minutes to 2 hours
- Leaves viruses bioactive
- Increases subsequent PCR sensitivity 10,000-fold
- Detects viruses even from minute concentrations
- Multiple virus detection in a single test or increased speed for single type deposition
- Does not require labels
No sample preparation
- Detects viruses directly from blood, serum, water and other raw samples
- Portable AFMs are already available and BioForce is working on a portable ViriChipTM Reader
Lynch, M.; Mosher, C.; Huff, J.; Nettikadan, S.; Johnson, J. and E. Henderson: Functional protein nanoarrays for biomarker profiling. Proteomics 4: 1695-1702, 2004.
Nettikadan, S.; Johnson, J.; Vengasandra, S.G.; Muys, J. and E. Henderson: ViriChip: a solid phase assay for detection and identification of viruses by atomic force microscopy. Nanotechnology 15: 383-389, 2004.
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